Bellicum Announces Data Presentations on Lead Product Candidate Rivo-cel and Controllable CAR Program at the 60th American Society of Hematology Annual Meeting
Nine abstracts accepted, including two oral presentations
Among the highlights will be late interim analyses from the BP-004 trial in children with acute leukemias and nonmalignant blood diseases, as well as the comparator C-004 trial—a multicenter, observational study of similar pediatric patients receiving a matched unrelated donor (MUD) transplant. As part of these interim analyses, the presentations will include the first reports of transplant Event-Free Survival at 180 days, the primary endpoint of the studies that will serve as the basis for MAA filing in
RIVO-CEL PRESENTATION DETAILS
Poster Presentation: “Administration of BPX-501 Cells Following αβ T and B-Cell-Depleted HLA-Haploidentical HSCT (haplo-HSCT) in Children with Malignant or Non-Malignant Disorders”
Abstract Number: 2171
Session Name: 732. Clinical Allogeneic Transplantation: Results: Poster I
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Oral Presentation: “Administration of BPX-501 Cells Following αβ T and B-Cell-Depleted HLA Haploidentical HSCT (haplo-HSCT) in Children with Acute Leukemias”
Abstract Number: 307
Session Name: 732. Clinical Allogeneic Transplantation: Results: Optimizing Outcomes After Allogeneic Transplantation
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Oral Presentation: “Administration of BPX-501 Following αβ T and B-cell Depleted Haplo-HSCT in Children with Transfusion-Dependent Thalassemia”
Abstract Number: 166
Session Name: 112. Thalassemia and Globin Gene Regulation: Clinical
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Poster Presentation: “Administration of Rimiducid Following Haploidentical BPX-501 Cells in Children with Malignant or Non-Malignant Disorders Who Develop Graft-versus-Host-Disease (GvHD)”
Abstract Number: 2207
Session Name: 801. Gene Therapy and Transfer: Poster I
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Poster Presentation: “Characterization of Allogeneic T Cells Expressing Inducible Caspase-9 Following Adoptive Transfer in Children Receiving an HLA-Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Myeloid Malignancies”
Abstract Number: 4534
Session Name: 703. Adoptive Immunotherapy: Poster III
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Poster Presentation: “Differential Expression of Inducible Caspase-9 (iC9) in Allogeneic T cells Allows Selective Depletion of Activated T Cells Following Exposure to Rimiducid and Permits In Vivo Allodepletion”
Abstract Number: 3496
Session Name: 801. Gene Therapy and Transfer: Poster II
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Poster Presentation: “Administration of BPX-501 Cells Following αβ T and B-Cell-Depleted HLA-Haploidentical HSCT in Children with Fanconi Anemia”
Abstract Number: 4654
Session Name: 732. Clinical Allogeneic Transplantation: Results: Poster III
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Poster Presentation: “A Simplified Method for Transduction and Expansion of T Cells for Clinical Application”
Abstract Number: 4555
Session Name: 711. Cell Collection and Processing: Poster III
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CONTROLLABLE CAR PRESENTATION DETAILS
Poster Presentation: “Regulated Natural Killer Cell Expansion and Anti-Tumor Activity with Inducible MyD88/CD40”
Abstract Number: 4550
Session Name: 703. Adoptive Immunotherapy: Poster III
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Presentation Time: 6:00 p.m. - 8:00 p.m. PT
About Bellicum Pharmaceuticals
Bellicum is a clinical stage biopharmaceutical company striving to deliver cures through controllable cell therapies. The Company’s next-generation product candidates are differentiated by powerful cell signaling technologies designed to produce more effective CAR-T, TCR and allogeneic T cell therapies. Its lead product candidate, rivo-cel, is an allogeneic polyclonal T cell product that has shown promising results in reducing leukemia relapse after a stem cell transplant. Bellicum’s lead GoCAR-T candidate, BPX-601, is designed to be a more efficacious CAR-T cell product capable of overriding key immune inhibitory mechanisms. More information can be found at www.bellicum.com.
Source:
Investors: Solebury TroutChad Rubin 646-378-2947 crubin@soleburytrout.com Media: Solebury TroutBrad Miles 646-513-3125 bmiles@soleburytrout.com
Source: Bellicum Pharmaceuticals, Inc.