July 29, 2019 Richard A. Fair President and Chief Executive Officer Bellicum Pharmaceuticals, Inc. 2130 W. Holcombe Blvd., Suite 800 Houston, TX 77030 Re: Bellicum Pharmaceuticals, Inc. Registration Statement on Form S-3 Filed July 23, 2019 File No. 333-232771 Dear Mr. Fair: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Christine Westbrook at 202-551-5019 with any questions. Sincerely, Division of Corporation Finance Office of Healthcare & Insurance cc: Karen Deschaine Anderson, Esq.